Steroidal alkaloids from Veratrum japonicum with genotoxicity on brain cell DNA of the cerebellum and cerebral cortex in mice

被引：22

作者：

Cong, Yue ^{[3
]}

Guo, Lei ^{[2
]}

Yang, Jing-Yu ^{[2
]}

Li, Ling ^{[2
]}

Zhou, Yu-Bo ^{[1
]}

Chen, Jing ^{[1
]}

Wang, Jin-Hui ^{[1
,4
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Life Sci & Biol Pharm, Shenyang 110016, Peoples R China

[3] Henan Univ, Sch Pharm, Inst Tradit Chinese Med, Kaifeng, Peoples R China

[4] Shihezi Univ, Shihezi, Peoples R China

来源：

PLANTA MEDICA | 2007年 / 73卷 / 15期

关键词：

Liliaceae; Veratrum japonicum (Baker) Loes. f; neogermine; genotoxicity;

D O I：

10.1055/s-2007-993750

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new steroidal alkaloid (1), together with three known steroidal alkaloids (2-4), has been isolated from the roots and rhizomes of Veratrum japonicum (Baker) Loes. f.., their structures were established as neogermine (1), germine (2), germerine (3), and neogermbudine (4) by means of physicochemical properties and spectroscopic analysis. Compounds 1-4 exhibited genotoxicity on brain cells in mice by using single-cell gel electrophoresis (Comet assay).

引用

页码：1588 / 1591

页数：4

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