Enantioselective addition of nitromethane to α-keto esters catalyzed by copper(II)-iminopyridine complexes

被引：48

作者：

Blay, Gonzalo ^{[1
]}

Hernandez-Olmos, Victor ^{[1
]}

Pedro, Jose R. ^{[1
]}

机构：

[1] Univ Valencia, Fac Quim, Dept Quim Organ, E-46100 Burjassot, Valencia, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 03期

关键词：

D O I：

10.1039/b716446g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The copper complex of a chiral iminopyridine easily prepared from (R)-(-)-fenchone and picolylamine catalyzes the enantioselective Henry (nitroaldol) reaction between nitromethane and alpha-keto esters. Good yields and modest to good enantioselectivities are obtained for a wide range of alpha-keto esters, bearing aromatic, alkyl or alkenyl groups attached to the ketone carbonyl group.

引用

页码：468 / 476

页数：9

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