5-HT4 receptors:: Cloning and expression of new splice variants

被引：37

作者：

Claeysen, S

Faye, P

Sebben, M

Taviaux, S

Bockaert, J

Dumuis, A

机构：

[1] CNRS, INSERM, Ctr Pharmacol Endocrinol, UPR 9023, F-34094 Montpellier 5, France

[2] Lab Fournier SCA, F-21121 Daix, France

[3] CRBM, CNRS, F-34293 Montpellier 5, France

来源：

ADVANCES IN SEROTONIN RECEPTOR RESEARCH: MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND THERAPEUTICS | 1998年 / 861卷

关键词：

D O I：

10.1111/j.1749-6632.1998.tb10172.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

On the basis of differences in the potencies and intrinsic activity of 5-HT4 receptor agonists in different biological models it has been suggested that there is heterogeneity among 5-HT4 receptors. Here, we report the molecular cloning of several 5-HT4 receptor splice variants in mouse, rat, and human brain. Our data suggest that the differences in efficacy of 5-HT4 ligands on 5-HT4 receptor-mediated responses in several tis sues is due to differences in coupling efficiency rather than to the presence of different 5-HT4 receptor isoforms.

引用

页码：49 / 56

页数：8

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