Vascular tissue engineering

被引:342
作者
Nerem, RM [1 ]
Seliktar, D [1 ]
机构
[1] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Georgia Tech Emory Ctr Engn Living Tissues, Atlanta, GA 30332 USA
关键词
blood vessel substitute; cell scaffold; smooth muscle cells; endothelial cells; in vitro development; tissue engineering;
D O I
10.1146/annurev.bioeng.3.1.225
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The development of a tissue-engineered blood vessel substitute has motivated much of the research in the area of cardiovascular tissue engineering over the past 20 years. Several methodologies have emerged for constructing blood vessel replacements with biological functionality. These include cell-seeded collagen gels, cell-seeded biodegradable synthetic polymer scaffolds, cell self-assembly, and acellular techniques. This review details the most recent developments, with a focus on core technologies and construct development. Specific examples are discussed to illustrate both the benefits and shortcomings of each methodology, as well as to underline common themes. Finally, a brief perspective on challenges for the future is presented.
引用
收藏
页码:225 / 243
页数:21
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