A global assembly line for cyanobactins

被引：214

作者：

Donia, Mohamed S. ^{[1
]}

Ravel, Jacques ^{[2
]}

Schmidt, Eric W. ^{[1
]}

机构：

[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[2] Univ Maryland, Dept Microbiol & Immunol, Inst Genome Sci, Sch Med, Baltimore, MD 21201 USA

来源：

NATURE CHEMICAL BIOLOGY | 2008年 / 4卷 / 06期

关键词：

D O I：

10.1038/nchembio.84

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering.

引用

页码：341 / 343

页数：3

共 15 条

[1] Tenuecyclamides A-D, cyclic hexapeptides from the cyanobacterium Nostoc spongiaeforme var. tenue [J].

Banker, R ;

Carmeli, S .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (10) :1248-1251

[2] Patellins 1-6 and trunkamide A: Novel cyclic hexa-, hepta- and octa-peptides from colonial ascidians, Lissoclinum sp [J].

Carroll, AR ;

Coll, JC ;

Bourne, DJ ;

MacLeod, JK ;

Zabriskie, TM ;

Ireland, CM ;

Bowden, BF .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1996, 49 (06) :659-667

[3] ASCIDIANS - PRODUCERS OF AMINO-ACID DERIVED METABOLITES [J].

DAVIDSON, BS .

CHEMICAL REVIEWS, 1993, 93 (05) :1771-1791

[4] NEW CYCLIC-PEPTIDES WITH CYTO-TOXIC ACTIVITY FROM THE ASCIDIAN LISSOCLINUM-PATELLA [J].

DEGNAN, BM ;

HAWKINS, CJ ;

LAVIN, MF ;

MCCAFFREY, EJ ;

PARRY, DL ;

VANDENBRENK, AL ;

WATTERS, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (06) :1349-1354

[5] Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians [J].

Donia, Mohamed S. ;

Hathaway, Brian J. ;

Sudek, Sebastian ;

Haygood, Margo G. ;

Rosovitz, M. J. ;

Ravel, Jacques ;

Schmidt, Eric W. .

NATURE CHEMICAL BIOLOGY, 2006, 2 (12) :729-735

[6] ANTI-NEOPLASTIC CYCLIC-PEPTIDES FROM THE MARINE TUNICATE LISSOCLINUM-PATELLA [J].

IRELAND, CM ;

DURSO, AR ;

NEWMAN, RA ;

HACKER, MP .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (10) :1807-1811

[7] From peptide precursors to oxazole and thiazole-containing peptide antibiotics: Microcin B17 synthase [J].

Li, YM ;

Milne, JC ;

Madison, LL ;

Kolter, R ;

Walsh, CT .

SCIENCE, 1996, 274 (5290) :1188-1193

[8] Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production [J].

Long, PF ;

Dunlap, WC ;

Battershill, CN ;

Jaspars, M .

CHEMBIOCHEM, 2005, 6 (10) :1760-1765

[9] Spontaneity in the patellamide biosynthetic pathway [J].

Milne, BF ;

Long, PF ;

Starcevic, A ;

Hranueli, D ;

Jaspars, M .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2006, 4 (04) :631-638

[10] Solution structure of the antitumor candidate trunkamide A by 2D NMR and restrained simulated annealing methods [J].

Salvatella , X ;

Caba, JM ;

Albericio, F ;

Giralt, E .

JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (02) :211-215

← 1 2 →