Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism

被引：148

作者：

Breitschopf, K ^{[1
]}

Zeiher, AM ^{[1
]}

Dimmeler, S ^{[1
]}

机构：

[1] Univ Frankfurt, Dept Internal Med 4, Div Mol Cardiol, D-60590 Frankfurt, Germany

来源：

FEBS LETTERS | 2001年 / 493卷 / 01期

关键词：

aging; endothelium; atherosclerosis; oxidized low density lipoprotein;

D O I：

10.1016/S0014-5793(01)02272-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advanced aging may contribute to impairment of angiogenesis and development df vascular diseases. Telomerase was shown to delay endothelial cell (EC) senescence, Therefore, we determined the regulation of telomerase activity in EC, Inhibition of phosphoinositol 3-kinase (PI3K) suppressed telomerase activity, whereas inhibitors directed against ERK1/2 or protein kinase C had no effect, Dominant negative Akt significantly reduced telomerase activity, Moreover, pro-atherogenic stimuli such as oxidized low density lipoprotein led to an inactivation of Akt and diminished telomerase activity, Thus, the PI3K/Akt pathway plays an important role in the regulation of telomerase activity. Pro-atherosclerotic factors impair telomerase activity and thereby may promote EC aging, (C) 2001 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.

引用

页码：21 / 25

页数：5

共 28 条

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