Costimulation of naive CD8+ lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection

被引：102

作者：

Kitchen, SG

Korin, YD

Roth, MD

Landay, A

Zack, JA

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Med, Ctr Hlth Sci,Div Hematol Oncol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Med, Div Pulm & Crit Care, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Sch Med, Dept Microbiol & Mol Genet, Los Angeles, CA 90095 USA

[5] Rush Presbyterian St Lukes Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60612 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 11期

关键词：

D O I：

10.1128/JVI.72.11.9054-9060.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD 1. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA(+) cells responded with greater expression of CD4 than did CD45RO(+) cells. CD8(+) lymphocytes derived from fetal or newborn sources exhibited a greater tendency to express CD4, consistent with their naive states. This mechanism of infection suggests HIV-induced perturbation of the CD8 arm of the immune response and could explain the generally rapid disease progression seen in HIV-infected children.

引用

页码：9054 / 9060

页数：7

共 42 条

[21] Human CD14(+) leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4 [J].