G-quadruplex recognition by bis-indole carboxamides

被引：68

作者：

Dash, Jyotirmayee ^{[1
]}

Shirude, Pravin S. ^{[1
]}

Balasubramanian, Shankar ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 26期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/b806042h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.

引用

页码：3055 / 3057

页数：3

共 47 条

[1] Gold(III)-catalyzed annulation of 2-alkynylanilines: A mild and efficient synthesis of indoles and 3-haloindoles [J].

Arcadi, A ;

Bianchi, G ;

Marinelli, F .

SYNTHESIS-STUTTGART, 2004, (04) :610-618

[2]

BALAGURUMOORTHY P, 1994, J BIOL CHEM, V269, P21858

[3]

Balasubramanian S, 2006, RSC BIOMOL SCI, pV

[4] Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression [J].

Bejugam, Mallesham ;

Sewitz, Sven ;

Shirude, Pravin S. ;

Rodriguez, Raphael ;

Shahid, Ramla ;

Balasubramanian, Shankar .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (43) :12926-+

[5] The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function [J].

Burger, AM ;

Dai, FP ;

Schultes, CM ;

Reszka, AP ;

Moore, MJ ;

Double, JA ;

Neidle, S .

CANCER RESEARCH, 2005, 65 (04) :1489-1496

[6] G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription [J].

Cogoi, Susanna ;

Xodo, Luigi E. .

NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2536-2549

[7] The Design of G-quadruplex Ligands as Telomerase Inhibitors [J].

Cuesta, Javier ;

Read, Martin A. ;

Neidle, Stephen .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (01) :11-21

[8] High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler [J].

Darby, RAJ ;

Sollogoub, M ;

McKeen, C ;

Brown, L ;

Risitano, A ;

Brown, N ;

Barton, C ;

Brown, T ;

Fox, KR .

NUCLEIC ACIDS RESEARCH, 2002, 30 (09) :e39

[9] Fluorescence-based melting assays for studying quadruplex ligands [J].

De Cian, Anne ;

Guittat, Lionel ;

Kaiser, Markus ;

Sacca, Barbara ;

Amrane, Samir ;

Bourdoncle, Anne ;

Alberti, Patrizia ;

Teulade-Fichou, Marie-Paule ;

Lacroix, Laurent ;

Mergny, Jean-Louis .

METHODS, 2007, 42 (02) :183-195

[10] Highly efficient G-quadruplex recognition by bisquinolinium compounds [J].

De Cian, Anne ;

DeLemos, Elsa ;

Mergny, Jean-Louis ;

Teulade-Fichou, Marie-Paule ;

Monchaud, David .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (07) :1856-+

← 1 2 3 4 5 →