Central mechanisms of osmosensation and systemic osmoregulation

被引:487
作者
Bourque, Charles W. [1 ]
机构
[1] McGill Univ, Montreal Gen Hosp, Ctr Hlth, Res Inst,Ctr Res Neurosci, Montreal, PQ H3G 1A4, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1038/nrn2400
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Systemic osmoregulation is a vital process whereby changes in plasma osmolality, detected by osmoreceptors, modulate ingestive behaviour, sympathetic outflow and renal function to stabilize the tonicity and volume of the extracellular fluid. Furthermore, changes in the central processing of osmosensory signals are likely to affect the hydro-mineral balance and other related aspects of homeostasis, including thermoregulation and cardiovascular balance. Surprisingly little is known about how the brain orchestrates these responses. Here, recent advances in our understanding of the molecular, cellular and network mechanisms that mediate the central control of osmotic homeostasis in mammals are reviewed.
引用
收藏
页码:519 / 531
页数:13
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