Channel-tunnels

被引：26

作者：

Koronakis, V ^{[1
]}

Andersen, C ^{[1
]}

Hughes, C ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-440X(00)00224-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TolC and its many homologues comprise an alpha -helical transperiplasmic tunnel embedded in the bacterial outer membrane by a contiguous beta -barrel channel, providing a large exit duct for diverse substrates. The 'channel-tunnel' is closed at its periplasmic entrance, but can be opened by an 'iris-like' mechanism when recruited by substrate-engaged proteins in the cytosolic membrane.

引用

页码：403 / 407

页数：5

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