The asymmetric Horner-Emmons reaction using a benzopyrano-isoxazolidine auxiliary

被引：54

作者：

Abiko, A ^{[1
]}

Masamune, S ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)02352-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric Horner-Emmons reaction of the phosphonate derived from a chiral benzopyrano-isoxazolidine (with 4-substituted cyclohexanones) proceeded in high diastereoselectivity with the aid of KHMDS and 18-crown-6 ether. Enantiomerically pure, axially dissymmetric cyclohexylidene alcohols, aldehydes and ketones were obtained from the diastereomerically pure Homer-Emmons products in a single step.

引用

页码：1077 / 1080

页数：4

共 22 条

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