First examples of improved catalytic asymmetric C-C bond formation using the monodentate ligand combination approach

被引：125

作者：

Duursma, A ^{[1
]}

Hoen, R ^{[1
]}

Schuppan, J ^{[1
]}

Hulst, R ^{[1
]}

Minnaard, AJ ^{[1
]}

Feringa, BL ^{[1
]}

机构：

[1] Univ Groningen, Dept Organ & Mol Inorgan Chem, Stratingh Inst, NL-9747 AG Groningen, Netherlands

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 17期

关键词：

D O I：

10.1021/ol035106o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using a combination of chiral monodentate phosphoramidite ligands in the rhodium-catalyzed conjugate addition of boronic acids to three different substrates, we have shown for the first time that the ligand combination approach is applicable for C-C bond formation. Chiral catalysts based on hetero-combinations of ligands are found to be more effective than the homo-combinations. P-31 NMR experiments show that the hetero-combinations are formed in excess over the homo-combinations.

引用

页码：3111 / 3113

页数：3

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