Erroneously low or undetectable plasma human immunodeficiency virus type 1 (HIV-1) ribonucleic acid load determined by polymerase chain reaction, in West African and American patients with non-B subtype HIV-1 infection

被引：45

作者：

Jenny-Avital, ER

Beatrice, ST

机构：

[1] Jacobi Med Ctr, Albert Einstein Coll Med, AIDS Consultat Serv, Bronx, NY USA

[2] New York City Dept Hlth, Bur Labs, Retrovirol & Immunobiol Div, New York, NY 10013 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2001年 / 32卷 / 08期

关键词：

D O I：

10.1086/319752

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The polymerase chain reaction (PCR) assay for plasma human immunodeficiency virus type 1 (HIV-1) ribonucleic acid (RNA) inadequately quantitates virus load for some non-B HIV-1 subtypes because of genetic diversity in the gag region targeted by the PCR primers. Unexpectedly low or undetectable plasma HIV-1 RNA findings by PCR were a clue to non-B HIV-1 infections in patients in whom plasma HIV-1 RNA was found to be substantially higher when determined by a branched-chain deoxyribonucleic acid assay.

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页码：1227 / 1230

页数：4

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