SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population

被引：21

作者：

Aoki, Asako ^{[2
]}

Ozaki, Kouichi

Sato, Hiroshi ^{[3
]}

Takahashi, Atsushi ^{[4
]}

Kubo, Michiaki ^{[5
]}

Sakata, Yasuhiko ^{[6
]}

Onouchi, Yoshihiro

Kawaguchi, Takahisa ^{[7
]}

Lin, Tsung-Hsien ^{[8
,9
]}

Takano, Hitoshi ^{[2
]}

Yasutake, Masahiro ^{[2
]}

Hsu, Po-Chao ^{[8
]}

Ikegawa, Shiro ^{[10
]}

Kamatani, Naoyuki ^{[4
]}

Tsunoda, Tatsuhiko ^{[7
]}

Juo, Suh-Hang H. ^{[11
,12
,13
]}

Hori, Masatsugu ^{[6
]}

Komuro, Issei ^{[6
]}

Mizuno, Kyoichi ^{[2
]}

Nakamura, Yusuke

Tanaka, Toshihiro ^{[1
]}

机构：

[1] RIKEN, Ctr Genom Med, Lab Cardiovasc Dis, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[2] Nippon Med Sch, Dept Med, Div Cardiol, Tokyo 113, Japan

[3] Kwansei Gakuin Univ, Sch Human Welf Studies, Nishinomiya, Hyogo, Japan

[4] RIKEN, Ctr Genom Med, Lab Stat Anal, Yokohama, Kanagawa 2300045, Japan

[5] RIKEN, Ctr Genom Med, Lab Genotyping Dev, Yokohama, Kanagawa 2300045, Japan

[6] Osaka Univ, Grad Sch Med, Dept Cardiovasc Med, Suita, Osaka, Japan

[7] RIKEN, Ctr Genom Med, Lab Med Informat, Yokohama, Kanagawa 2300045, Japan

[8] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan

[9] Kaohsiung Med Univ, Dept Internal Med, Kaohsiung, Taiwan

[10] RIKEN, Ctr Genom Med, Lab Bone & Joint Dis, Tokyo, Japan

[11] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan

[12] Kaohsiung Med Univ, Grad Inst Med Genet, Kaohsiung, Taiwan

[13] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung, Taiwan

来源：

JOURNAL OF HUMAN GENETICS | 2011年 / 56卷 / 01期

关键词：

association; genome; myocardial infarction; SNP; CONFERS RISK; FUNCTIONAL SNP; SUSCEPTIBILITY; GENOME; GENE; IDENTIFICATION; LOCUS;

D O I：

10.1038/jhg.2010.141

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P = 5.3 x 10(-13), odds ratio = 0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI. Journal of Human Genetics (2011) 56, 47-51; doi:10.1038/jhg.2010.141; published online 25 November 2010

引用

页码：47 / 51

页数：5

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