Bacterial magnetic nanoparticles for photothermal therapy of cancer under the guidance of MRI

The bacterial magnetic nanoparticles (BMPs) are biomineralized by the magnetotactic bacteria and naturally covered with a layer of biomembrane. Herein, BMPs were isolated and firstly used for the photothermal therapy (PTT) of cancer under the guidance of magnetic resonance imaging (MRI) in vitro and in vivo. The results showed that BMPs could rapidly convert the energy of 808 nm near-infrared (NIR) light into heat. After internalization by the HepG2 tumor cells, BMPs with good biocompatibility could induce an efficient killing effect after NIR light irradiation, along with a change of mitochondrial membrane potential (Delta Psi(m)) and level of intracellular reactive oxygen species (ROS). The in vivo therapy also confirms that PIT with BMPs could effectively and completely ablate the tumor in mice without inducing observable toxicity. T-2-weighted MRI showed a clear tumor boundary and a 25% enhancement of negative contrast enhancement at the tumor site, suggesting that BMPs can act as an effective MRI contrast agent for guiding the PIT. Our results indicate that BMPs could be a potential theranostic agent for simultaneous MRI and PIT of cancer. (C) 2016 Elsevier Ltd. All rights reserved.