Staphylococcus aureus Nonribosomal Peptide Secondary Metabolites Regulate Virulence

被引：104

作者：

Wyatt, Morgan A. ^{[1
]}

Wang, Wenliang ^{[1
]}

Roux, Christelle M. ^{[2
]}

Beasley, Federico C. ^{[3
,4
]}

Heinrichs, David E. ^{[3
,4
]}

Dunman, Paul M. ^{[2
]}

Magarvey, Nathan A. ^{[1
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Dept Chem & Chem Biol, MG DeGroote Inst Infect Dis Res, Hamilton, ON L8N 3Z5, Canada

[2] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA

[3] Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 5C1, Canada

[4] Univ Western Ontario, Ctr Human Immunol, London, ON N6A 5C1, Canada

来源：

SCIENCE | 2010年 / 329卷 / 5989期

基金：

加拿大健康研究院;

关键词：

NATURAL-PRODUCT; CLUMPING FACTOR; PATHOGENESIS; ANTIBIOTICS; EXPRESSION; BINDING; PROTEIN; GENES;

D O I：

10.1126/science.1188888

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Staphylococcus aureus is a major human pathogen that is resistant to numerous antibiotics in clinical use. We found two nonribosomal peptide secondary metabolites-the aureusimines, made by S. aureus-that are not antibiotics, but function as regulators of virulence factor expression and are necessary for productive infections. In vivo mouse models of bacteremia showed that strains of S. aureus unable to produce aureusimines were attenuated and/or cleared from major organs, including the spleen, liver, and heart. Targeting aureusimine synthesis may offer novel leads for anti-infective drugs.

引用

页码：294 / 296

页数：3

共 28 条

[1] PHEVALIN, A NEW CALPAIN INHIBITOR, FROM A STREPTOMYCES SP [J].