Identification of Bach2 as a B-cell-specific partner for small Maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer

被引:155
作者
Muto, A
Hoshino, H
Madisen, L
Yanai, N
Obinata, M
Karasuyama, H
Hayashi, M
Nakauchi, H
Yamamoto, M
Groudine, M
Igarashi, K [1 ]
机构
[1] Tohoku Univ, Sch Med, Dept Biochem, Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 305, Japan
[3] Univ Tsukuba, Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 305, Japan
[4] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
[5] Tohoku Univ, Inst Dev Aging & Canc, Dept Cell Biol, Sendai, Miyagi 980, Japan
[6] Tokyo Metropolitan Inst Med Sci, Dept Immunol, Bunkyo Ku, Tokyo 113, Japan
关键词
B cell; immunoglobulin; Maf; transcription factor;
D O I
10.1093/emboj/17.19.5734
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Maf family transcription factors are important regulators in various differentiation systems. Putative Maf recognition elements (MAREs) are found in the 3' enhancer region of the immunoglobulin heavy chain (IgH) gene. These elements are bound in B-cell extracts by a heterodimeric protein complex containing both Bach2 and a small Maf protein. Analysis of normal hematopoietic cells revealed that Bach2 is specifically expressed in B cells. Bach2 is abundantly expressed in the early stages of B-cell differentiation and turned off in terminally differentiated cells. Bach2 acts together with MafK as a negative effector of the IgH 3' enhancer and hinds to the to-repressor SMRT (silencing mediator of retinoid and thyroid receptor). Hence the Bach2-small-Maf heterodimer may represent the first example of a B-cell lineage, and of a developmental stage-restricted negative effector of the MARE in the IgH 3' enhancer region.
引用
收藏
页码:5734 / 5743
页数:10
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