BCG modulation of anaphylactic antibody response, airway inflammation and lung hyperreactivity in genetically selected mouse strains (Selection IV-A)

被引：1

作者：

Barros, MT

Acencio, MMP

Garcia, MLB

Soares, MFM

Ibañez, OM

Martins, MA

Ribeiro, OG

Kalil, J

Perini, A

机构：

[1] Univ Sao Paulo, Dept Med, Div Gen Internal Med, Div Clin Immunol & Alergy,Heart Inst,InCor, BR-01246903 Sao Paulo, Brazil

[2] Univ Sao Paulo, Dept Med, Div Gen Internal Med, Lab Pleura Div,Heart Inst,InCor, BR-01246903 Sao Paulo, Brazil

[3] Butantan Inst, Immunopathol Lab, Sao Paulo, Brazil

[4] Butantan Inst, Immunogenet Lab, Sao Paulo, Brazil

来源：

LIFE SCIENCES | 2005年 / 77卷 / 13期

基金：

巴西圣保罗研究基金会;

关键词：

BCG; anaphylactic antibodies; bronchial hyperresponsiveness; selected mice (Selection IV-A);

D O I：

10.1016/j.lfs.2005.04.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of Bacillus Calmette-Guerin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 anti-OVA, eosinophils in pulmonary tissue, inflammatory cells in bronchoalveolar lavage and the compliance and conductance of respiratory system were evaluated. H-IVA mice were found more susceptible than L-IVA, and BCG was able to inhibit simultaneously the production of IgE, the bronchopulmonary inflammation and bronchial hyperresponsiveness in these genetically selected mice. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1480 / 1492

页数：13

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