One-pot, large-scale synthesis of Nickel(II) complexes derived from 2-[N-(α-Picolyl)amino]benzophenone (PABP) and α- or β-Amino acids

被引：30

作者：

Deng, Guanghui

Wang, Jiang

Zhou, Yu

Jiang, Hualiang

Liu, Hong

机构：

[1] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci,Drug Discovery & Design Ct, Shanghai Inst Mat Med,State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China

[3] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 23期

关键词：

D O I：

10.1021/jo071011e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A one-pot, large-scale procedure for preparing the Belokon-Soloshonok nucleophilic glycine equivalent 2-[N(alpha-picolyl)amino]benzophenone (PABP) derived Ni(II) complex [GLyNi(II)PABP] is described. It has been accomplished by using isobutyl chloroformate to form PABP and then NaH/KOH as mixed bases to afford the corresponding complexes in a one-pot manner (up to an overall yield of 98%). The potential of this method for preparation of beta-amino acids derivatives, such as beta-AlaNi(II)PABP and beta-PheNi(II)PABP, has been demonstrated. The structure of beta-AlaNi(II)PABP is characterized by single-crystal X-ray diffraction.

引用

页码：8932 / 8934

页数：3

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