Facile synthesis of substituted 2,3,4,7-tetrahydro-1H-azepines via ring-closing metathesis

被引：19

作者：

Brass, S ^{[1
]}

Gerber, HD ^{[1
]}

Dörr, S ^{[1
]}

Diederich, WE ^{[1
]}

机构：

[1] Univ Marburg, Inst Pharmazeut Chem, Fachbereich Pharm, D-35037 Marburg, Germany

来源：

TETRAHEDRON | 2006年 / 62卷 / 08期

关键词：

azacycles; lactames; beta-amino ester;

D O I：

10.1016/j.tet.2005.11.049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient synthesis based on inexpensive and readily available starting material towards the pharmacologically interesting class Of Substituted 2,3,4,7-tetrahydro-1H-azepines via a ring-closing metathesis (RCM) approach employing Grubbs catalysts 1 and 2 is described. The influence of the substituents R-1 and R-2 on the outcome of the RCM reaction is discussed. The seemingly first example of an RCM approach towards seven-membered azacycles bearing a substituent at the alkene moiety Utilizing Grubbs catalyst 1 is presented. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1777 / 1786

页数：10

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