High performance cocktail functional monomer for making molecule imprinting polymer

被引：23

作者：

Meng, ZH ^{[1
]}

Wang, JF ^{[1
]}

Zhou, LM ^{[1
]}

Wang, QH ^{[1
]}

Zhu, DQ ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem & Phys, Dalian 116012, Peoples R China

来源：

ANALYTICAL SCIENCES | 1999年 / 15卷 / 02期

关键词：

molecule imprinting; enantiomer separation; chiral stationary phase; amino acid;

D O I：

10.2116/analsci.15.141

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In order to make a molecule imprinting polymer (MIP) with highly chiral selectivity against N-t-Boc-L-Trp, a new kind of "cocktail" functional monomer: acrylamide+2-vinylpyridine was investigated. The MIP showed impressive chiral selectivity (alpha=3.23). With the increasing of water content in the mobile phase, ionic and hydrophobic interaction were found to be responsible for the chiral recognition process instead of the hydrogen bond. Tailing and peak asymmetry problems were overcome by using linear gradient elution. Physical properties such as thermal stability and pore structure for the MIP were also investigated.

引用

页码：141 / 144

页数：4

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