Haemostatic changes in pregnancy

被引：350

作者：

Bremme, KA ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Hosp, Dept Obstet & Gynecol, Dept Women & Child Hlth, SE-17176 Stockholm, Sweden

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2003年 / 16卷 / 02期

关键词：

normal pregnancy; delivery; post-partum; coagulation; fibrinolysis; haemostasis;

D O I：

10.1016/S1521-6926(03)00021-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Normal pregnancy is accompanied by changes in the coagulation and fibrinolytic systems. These include increases in a number of clotting factors (I, II, VII, VIII, IX and XII), a decrease in protein S levels and inhibition of fibrinolysis. As gestation progresses, there is also a significant fall in the activity of activated protein C, an important anticoagulant. While these physiological changes may be important for minimizing intrapartum blood loss, they entail an increased risk of thromboembolism during pregnancy and the post-partum period.

引用

页码：153 / 168

页数：16

共 90 条

[41]

DENG LP, 1994, OBSTET GYNECOL, V84, P941

[42] Fluctuations in levels of antiphospholipid antibodies and increased coagulation activation markers in normal and heparin-treated antiphospholipid syndrome pregnancies [J].