An assessment of the genetic toxicology of antimony trioxide

被引：24

作者：

Elliott, BM ^{[1
]}

Mackay, JM ^{[1
]}

Clay, P ^{[1
]}

Ashby, J ^{[1
]}

机构：

[1] ICI PLC, Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 1998年 / 415卷 / 1-2期

关键词：

antimony trioxide; genetic toxicology; mutation; cytogenetics; DNA repair;

D O I：

10.1016/S1383-5718(98)00065-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antimony trioxide (Sb2O3, CAS 1309-64-4) has been examined in a range of in vitro and in vivo genotoxicity assays. Negative results were obtained with the Salmonella/microsome assay and the L5178Y mutation assay, but a positive response was observed in the in vitro cytogenetic assay using isolated human peripheral lymphocytes. However, in vivo, antimony trioxide was non-clastogenic in the mouse bone marrow micronucleus assay, following oral gavage administration for 1, 7, 14 or 21 days at dose levels of up to 5000 mg/kg (single dose) or 1000 mg/kg (repeat dose). A negative result was also obtained in the in vivo rat liver DNA repair (unscheduled DNA synthesis) assay following a single oral gavage administration of doses up to 5000 mg/kg. These data show no genotoxicity for antimony trioxide in vivo and do not confirm a previous report of clastogenicity in the mouse on repeated dosing. It is concluded that antimony trioxide is not genotoxic in vivo and does not present a genotoxic hazard to humans. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：109 / 117

页数：9