Bile acid and xenobiotic transporters in liver

被引：53

作者：

Stieger, B ^{[1
]}

Meier, PJ ^{[1
]}

机构：

[1] Univ Zurich Hosp, Dept Med, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(98)80059-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Identification of transporters involved in bile formation in liver is rapidly progressing. It is now clear that these transporters are also important in drug disposition in the body. Significant recent advances include the cloning of an ATP-dependent bile acid transporter related to the p-glycoprotein family, in the canalicular plasma membrane of hepatocytes, In addition, liver transporter genes responsible for hereditary forms of cholestatic liver disease have been identified and found to belong to the superfamily of ATP-binding cassette proteins.

引用

页码：462 / 467

页数：6

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