Bile acid and xenobiotic transporters in liver

被引：53

作者：

Stieger, B ^{[1
]}

Meier, PJ ^{[1
]}

机构：

[1] Univ Zurich Hosp, Dept Med, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(98)80059-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Identification of transporters involved in bile formation in liver is rapidly progressing. It is now clear that these transporters are also important in drug disposition in the body. Significant recent advances include the cloning of an ATP-dependent bile acid transporter related to the p-glycoprotein family, in the canalicular plasma membrane of hepatocytes, In addition, liver transporter genes responsible for hereditary forms of cholestatic liver disease have been identified and found to belong to the superfamily of ATP-binding cassette proteins.

引用

页码：462 / 467

页数：6

共 55 条

[31] The secretory function of the liver:: new aspects of hepatobiliary transport [J].

Müller, M ;

Jansen, PLM .

JOURNAL OF HEPATOLOGY, 1998, 28 (02) :344-354

[32]

Nies AT, 1996, J LIPID RES, V37, P1125

[33] Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain [J].

Noe, B ;

Hagenbuch, B ;

Stieger, B ;

Meier, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10346-10350

[34] A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport [J].

Ortiz, DF ;

StPierre, MV ;

Abdulmessih, A ;

Arias, IM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (24) :15358-15365

[35] A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome [J].

Paulusma, CC ;

Kool, M ;

Bosma, PJ ;

Scheffer, GL ;

terBorg, F ;

Scheper, RJ ;

Tytgat, GNJ ;

Borst, P ;

Baas, F ;

Elferink, PJO .

HEPATOLOGY, 1997, 25 (06) :1539-1542

[36] Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene [J].

Paulusma, CC ;

Bosma, PJ ;

Zaman, GJR ;

Bakker, CTM ;

Otter, M ;

Scheffer, GL ;

Scheper, RJ ;

Borst, P ;

Elferink, RPJO .

SCIENCE, 1996, 271 (5252) :1126-1128

[37] Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume [J].

Roman, RM ;

Wang, Y ;

Lidofsky, SD ;

Feranchak, AP ;

Lomri, N ;

Scharschmidt, BF ;

Fitz, JG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (35) :21970-21976

[38]

Rosenberg MF, 1997, J BIOL CHEM, V272, P10685

[39] RETRACTED: Functional interactions between synthetic alkyl phospholipds and the ABC transporters P-glycoprotein, Ste-6, MRP, and Pgh-1 (Retracted article) [J].

Ruetz, S ;

Brault, M ;

Dalton, W ;

Gros, P .

BIOCHEMISTRY, 1997, 36 (26) :8180-8188

[40] Organic anion transporting polypeptide mediates organic anion/HCO3- exchange [J].

Satlin, LM ;

Amin, V ;

Wolkoff, AW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (42) :26340-26345

← 1 2 3 4 5 6 →