Effect of pre- versus post-weaning environmental disturbances on social behaviour in mice

被引：32

作者：

Bouet, Valentine ^{[1
]}

Lecrux, Blandine ^{[1
]}

Tran, Gwenaelle ^{[1
]}

Freret, Thomas ^{[1
]}

机构：

[1] Univ Caen Basse Normandie, GMPc, F-14032 Caen, France

来源：

NEUROSCIENCE LETTERS | 2011年 / 488卷 / 02期

关键词：

Maternal deprivation; Social isolation; Psychiatric disease; Social withdrawal; Memory; INBRED MOUSE STRAINS; ANIMAL-MODELS; WORKING-MEMORY; SCHIZOPHRENIA; SOCIABILITY; FEMALE;

D O I：

10.1016/j.neulet.2010.11.033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Environmental factors are involved to various degrees in psychiatric diseases. Unfortunately, early-life manipulations have been rarely investigated in mice. Interestingly, given the advances in genetics, combination of environmental and genetic factors to get construct validity is now possible. Herein, spontaneous activity, anxiety-like behaviour, social behaviour and short term spatial working memory were assessed in mice after maternal separation or social isolation. Of note, social withdrawal was observed in both models suggesting that this aspect needs to be better considered in future studies, particularly in testing new treatments for schizophrenia. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：221 / 224

页数：4

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