Polarizing the Nazarov cyclization: Efficient catalysis under mild conditions

被引：174

作者：

He, W ^{[1
]}

Sun, XF ^{[1
]}

Frontier, AJ ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 47期

关键词：

D O I：

10.1021/ja037910b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Substituted divinyl ketones were studied in the Nazarov cyclization. α-Carbomethoxy divinyl ketones underwent efficient Nazarov cyclization with catalytic copper triflate (2 mol %) to give a single cyclopentenone regio- and stereoisomer. The efficiency of the cyclizations correlated with the ability of the substituents to favorably polarize the π-system of the cationic intermediate. Copyright © 2003 American Chemical Society.

引用

页码：14278 / 14279

页数：2

共 27 条

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