Functional plasticity in cognitive aging: Review and hypothesis

被引：205

作者：

Greenwood, P. M. ^{[1
]}

机构：

[1] George Mason Univ, Dept Psychol, Arch Lab, Fairfax, VA 22030 USA

来源：

NEUROPSYCHOLOGY | 2007年 / 21卷 / 06期

关键词：

aging; adaptation; atrophy; hypothesis; cognition;

D O I：

10.1037/0894-4105.21.6.657

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Cognitive aging reflects not only loss but also adaptation to loss. The adult brain is capable of plastic change, including change in cortical representation. This has been seen in association not only with frank lesions but also in healthy individuals as a function of experience and training. This review considers the potential for adult plasticity together with evidence of a relation in old age between regional cortical atrophy/shrinkage and increased activation in neuroimaging. Those cortical regions shown most consistently to shrink in adulthood-prefrontal and parietal cortices-are the same regions showing increased regional activation in aging. Combining several strands of behavioral and neuroimaging evidence, the author argues that functional plasticity alters the course of cognitive aging. The author advances the hypothesis that losses in regional brain integrity drive functional reorganization through changes in processing strategy and makes specific predictions from that hypothesis.

引用

页码：657 / 673

页数：17

共 186 条

[51] Task-related activity in prefrontal cortex and its relation to recognition memory performance in young and old adults [J].

Grady, CL ;

McIntosh, AR ;

Craik, FIM .

NEUROPSYCHOLOGIA, 2005, 43 (10) :1466-1481

[52] Age-related differences in the functional connectivity of the hippocampus during memory encoding [J].

Grady, CL ;

McIntosh, AR ;

Craik, FIM .

HIPPOCAMPUS, 2003, 13 (05) :572-586

[53] Brain imaging and age-related changes in cognition [J].

Grady, CL .

EXPERIMENTAL GERONTOLOGY, 1998, 33 (7-8) :661-673

[54] Changes in memory processing with age [J].

Grady, CL ;

Craik, FI .

CURRENT OPINION IN NEUROBIOLOGY, 2000, 10 (02) :224-231

[55]

GRADY CL, 1989, COGN AG C ATL GEORG

[56] EFFECTS OF COMPLEX OR ISOLATED ENVIRONMENTS ON CORTICAL DENDRITES OF MIDDLE-AGED RATS [J].

GREEN, EJ ;

GREENOUGH, WT ;

SCHLUMPF, BE .

BRAIN RESEARCH, 1983, 264 (02) :233-240

[57] EVIDENCE FOR ACTIVE SYNAPSE FORMATION OR ALTERED POSTSYNAPTIC METABOLISM IN VISUAL-CORTEX OF RATS REARED IN COMPLEX ENVIRONMENTS [J].

GREENOUGH, WT ;

HWANG, HMF ;

GORMAN, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (13) :4549-4552

[58]

Greenwood P.M., 1994, AGING COGNITION, V1, P188, DOI [DOI 10.1080/13825589408256576, 10.1080/13825589408256576]

[59] The frontal aging hypothesis evaluated [J].

Greenwood, PM .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2000, 6 (06) :705-726

[60] Scaling of visuospatial attention undergoes differential longitudinal change as a function of APOE genotype prior to old age: Results from the NIMH BIOCARD study [J].

Greenwood, PM ;

Sunderland, T ;

Putnam, K ;

Levy, J ;

Parasuraman, R .

NEUROPSYCHOLOGY, 2005, 19 (06) :830-840

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