Preparation of enantioenriched α-silyl-benzylcarbamates

被引：26

作者：

Barberis, C ^{[1
]}

Voyer, N ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, St Foy, PQ G1K 7P4, Canada

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(98)01463-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first examples of an enantioselective [1,2] silicon rearrangement are reported. This novel synthetic method lead to the formation of chiral alpha-substituted benzylamines with an alpha-silyl group. In the procedure, N-Silyl-protected N-Boc benzylamines are subjected to enantioselective deprotonation using the chiral complex (-) sparteine.s-Buli to generate chiral benzyllithium intermediates that undergo a [1,2] silicon shift. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6807 / 6810

页数：4

共 11 条

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