Net, an Ets ternary complex transcription factor, is expressed in sites of vasculogenesis, angiogenesis, and chondrogenesis during mouse development

被引：44

作者：

Ayadi, A ^{[1
]}

Suelves, M ^{[1
]}

Dollé, P ^{[1
]}

Wasylyk, B ^{[1
]}

机构：

[1] ULP, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, F-67404 Illkirch, France

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 102卷 / 1-2期

关键词：

Net; SAP-2; ERP; ELK-3; ternary complex factors; Ets; transcription factor; in situ hybridization; vascular primordia; yolk sac; blood islands; allantois; heart endocardium; dorsal aortae; endothelia; facial mesenchyme; branchial arch; limb bud; cartilage; perichondrium; vasculogenesis; angiogenesis; VEGF-R2; Flk-1; angioblasts;

D O I：

10.1016/S0925-4773(01)00289-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Net gene encodes an Ets transcription factor belonging to the ternary complex Factor subfamily. We studied Net expression during mouse development (E7.5-E18.5) by in situ hybridization. Net is expressed at E7.5-8.5 in developing vascular primordia, including the allantoic vessels, heart endocardium and dorsal aortae. Vascular endothelial cell expression persists throughout development. Additional sites of expression appear at E9.5-E10.5, especially in facial, branchial arch and distal limb-bud mesenchyme. Later, expression is most conspicuous in developing cartilage and becomes progressively restricted to perichondrium. Net expression during mouse development correlates with vasculogenesis, angiogenesis and cartilage ontogeny. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：205 / 208

页数：4

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