Molecular genetics of Mycobacterium tuberculosis in relation to the discovery of novel drugs and vaccines

被引：20

作者：

Kana, BD

Mizrahi, V

机构：

[1] Univ Witwatersrand, Natl Hlth Lab Serv, MRC, NHLS,WITS Mol Mycobacteriol Res Unit, ZA-2000 Johannesburg, South Africa

[2] Univ Witwatersrand, Sch Pathol, ZA-2000 Johannesburg, South Africa

来源：

TUBERCULOSIS | 2004年 / 84卷 / 1-2期

关键词：

mycobacterium; tuberculosis; gene knockout; transposon; mycobacteriophage; target validation;

D O I：

10.1016/j.tube.2003.08.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genetic systems that allow mycobacterial genomes to be mutagenized in a targeted or random fashion have provided the means for developing new tools for the diagnosis, prevention and treatment of tuberculosis by allowing potential targets to be identified and validated. In this review, we highlight key historical developments in the field of mycobacterial. genetics, which have yielded the powerful repertoire of genetic tools that are now in hand and provide examples that illustrate their use in exploring specific aspects of mycobacterial metabolism. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：63 / 75

页数：13

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