In vivo imaging of malaria parasites -: recent advances and future directions

被引：42

作者：

Amino, R

Ménard, R

Frischknecht, F

机构：

[1] Inst Pasteur, Unite Biol & Genet Paludisme & Grand Programme Ho, F-75015 Paris, France

[2] Univ Fed Sao Paulo, Dept Biochem, BR-04044020 Sao Paulo, SP, Brazil

[3] Heidelberg Univ, Sch Med, Dept Parasitol, D-69120 Heidelberg, Germany

来源：

CURRENT OPINION IN MICROBIOLOGY | 2005年 / 8卷 / 04期

关键词：

D O I：

10.1016/j.mib.2005.06.019

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A new view into the life of malaria parasites is now possible owing to recent advances in imaging techniques and to the generation of tagged parasites. Insights into how parasites interact with their insect vectors and mammalian hosts have been gained by the study of various parasitic forms in their natural environment. Quantitative analysis of Plasmodium ookinete motility has revealed different modes of motility in parasite invasion of the mosquito gut and the extrusion of invaded gut cells from the epithelium. Similar analysis with Plasmodium sporozoites has revealed the importance of parasite motility in transmission from the mosquito vector to the mammalian host.

引用

页码：407 / 414

页数：8

共 79 条

[1] The signal sequence of exported protein-1 directs the green fluorescent protein to the parasitophorous vacuole of transfected malaria parasites [J].