The elusive malaria sporozoite in the mammalian host

被引：29

作者：

Baldacci, P ^{[1
]}

Ménard, R ^{[1
]}

机构：

[1] Inst Pasteur, Unite Biol & Genet Paludisme, Paris, France

来源：

MOLECULAR MICROBIOLOGY | 2004年 / 54卷 / 02期

关键词：

D O I：

10.1111/j.1365-2958.2004.04275.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malaria infection is initiated when Plasmodium sporozoites are injected into a host during the bite of an infected mosquito. In the mammal, the sporozoite must rapidly reach an intravacuolar niche within a hepatocyte, where it will generate the parasite stage that invades red blood cells and causes the symptoms of the disease. Herein, we describe our understanding of the way in which sporozoites travel from the site of the mosquito bite to the liver, arrest in the liver, cross the sinusoidal barrier and eventually gain access to hepatocytes. We also highlight some of the recent advances in our understanding of these processes at the molecular level.

引用

页码：298 / 306

页数：9

共 70 条

[1]

Adams JC, 2000, DEV DYNAM, V218, P280

[2]

BEIER MS, 1992, AM J TROP MED HYG, V47, P195

[3] Plasmodium yoelii sporozoites infect Syndecan-1 deficient mice [J].

Bhanot, P ;

Nussenzweig, V .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2002, 123 (02) :143-144

[4] Human antibodies against Plasmodium falciparum liver-stage antigen 3 cross-react with Plasmodium yoelii preerythrocytic-stage epitopes and inhibit sporozoite invasion in vitro and in vivo [J].

Brahimi, K ;

Badell, E ;

Sauzet, JP ;

BenMohamed, L ;

Daubersies, P ;

Guérin-Marchand, C ;

Snounou, G ;

Druilhe, P .

INFECTION AND IMMUNITY, 2001, 69 (06) :3845-3852

[5] Mosquito production mooted as fast track to malaria vaccine [J].

Butler, D .

NATURE, 2003, 425 (6957) :437-437

[6] Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii [J].

Carlton, JM ;

Angiuoli, SV ;

Suh, BB ;

Kooij, TW ;

Pertea, M ;

Silva, JC ;

Ermolaeva, MD ;

Allen, JE ;

Selengut, JD ;

Koo, HL ;

Peterson, JD ;

Pop, M ;

Kosack, DS ;

Shumway, MF ;

Bidwell, SL ;

Shallom, SJ ;

van Aken, SE ;

Riedmuller, SB ;

Feldblyum, TV ;

Cho, JK ;

Quackenbush, J ;

Sedegah, M ;

Shoaibi, A ;

Cummings, LM ;

Florens, L ;

Yates, JR ;

Raine, JD ;

Sinden, RE ;

Harris, MA ;

Cunningham, DA ;

Preiser, PR ;

Bergman, LW ;

Vaidya, AB ;

Van Lin, LH ;

Janse, CJ ;

Waters, AP ;

Smith, HO ;

White, OR ;

Salzberg, SL ;

Venter, JC ;

Fraser, CM ;

Hoffman, SL ;

Gardner, MJ ;

Carucci, DJ .

NATURE, 2002, 419 (6906) :512-519

[7] Hepatocyte growth factor and its receptor are required for malaria infection [J].

Carrolo, M ;

Giordano, S ;

Cabrita-Santos, L ;

Corso, S ;

Vigário, AM ;

Silva, S ;

Leiriao, P ;

Carapau, D ;

Armas-Portela, R ;

Comoglio, PM ;

Rodriguez, A ;

Mota, MM .

NATURE MEDICINE, 2003, 9 (11) :1363-1369

[8] THE BASOLATERAL DOMAIN OF THE HEPATOCYTE PLASMA-MEMBRANE BEARS RECEPTORS FOR THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM SPOROZOITES [J].

CERAMI, C ;

FREVERT, U ;

SINNIS, P ;

TAKACS, B ;

CLAVIJO, P ;

SANTOS, MJ ;

NUSSENZWEIG, V .

CELL, 1992, 70 (06) :1021-1033

[9] PfSPATR, a Plasmodium falciparum protein containing an altered thrombospondin type I repeat domain is expressed at several stages of the parasite life cycle and is the target of inhibitory antibodies [J].

Chattopadhyay, R ;

Rathore, D ;

Fujioka, H ;

Kumar, S ;

de la Vega, P ;

Haynes, D ;

Moch, K ;

Fryauff, D ;

Wang, RB ;

Carucci, DJ ;

Hoffman, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (28) :25977-25981

[10] STRUCTURE OF THE GENE ENCODING THE IMMUNODOMINANT SURFACE-ANTIGEN ON THE SPOROZOITE OF THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM [J].

DAME, JB ;

WILLIAMS, JL ;

MCCUTCHAN, TF ;

WEBER, JL ;

WIRTZ, RA ;

HOCKMEYER, WT ;

MALOY, WL ;

HAYNES, JD ;

SCHNEIDER, I ;

ROBERTS, D ;

SANDERS, GS ;

REDDY, EP ;

DIGGS, CL ;

MILLER, LH .

SCIENCE, 1984, 225 (4662) :593-599

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