Rapid assembly of polycyclic substances by a multicomponent cascade (4+2)-(2+2) cycloadditions: Total synthesis of the proposed structure of paesslerin A

被引：63

作者：

Inanaga, K ^{[1
]}

Takasu, K ^{[1
]}

Ihara, M ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Organ Chem, Sendai, Miyagi 9808578, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 05期

关键词：

D O I：

10.1021/ja039808k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile method for stereoselective formation of multisubstituted bicyclo[4.2.0]octane framework has been developed by means of catalytic (4 + 2)-(2 + 2) cycloaddition reactions. Its application to the synthesis of a substance reported to be the cytotoxic sesquiterpene, paesslerin A, is described, and it has been made clear that a revision of the structure of natural paesslerin A is required. Copyright © 2004 American Chemical Society.

引用

页码：1352 / 1353

页数：2

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