Presenilin 1:: more than just γ-secretase

被引：19

作者：

Raemaekers, T

Esselens, C

Annaert, W ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Human Genet, Lab Membrane Trafficking, B-3000 Louvain, Belgium

[2] VIB04, B-3000 Louvain, Belgium

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

关键词：

autophagy; hippocampal neuron; neurodegeneration; presenilin 1 (PS1); gamma-secretase; telencephalin (TLN);

D O I：

10.1042/BST0330559

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Presenilin 1 plays a central catalytic role in the gamma-secretase processing of amyloid precursor protein, Notch and many other substrates. However, this core component clearly mediates independently several other physiological roles in the cell/neuron. Besides its involvement in beta-catenin degradation, we discuss here the recent implication of presenilin 1 in the turnover of the intercellular cell adhesion molecule, telencephalin, through a degradation route that bears autophagic characteristics. Activation of the endosomal/lysosomal system in general and autophagic degradation in particular, is finally briefly discussed in the context of neurodegenerative diseases.

引用

页码：559 / 562

页数：4

共 42 条

[1] Mechanisms of phagocytosis in macrophages [J].