30 some years of heme oxygenase:: From a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events

被引：188

作者：

Maines, MD ^{[1
]}

Gibbs, PEM ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Biochem & Biophys, Rochester, NY 14624 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期

关键词：

HO-1 and HO-2; biliverdin reductase; HSP32; cognates; intracellular gas sensor; biliverdin/bilirubin; carbon monoxide; hypoxia/heme regulated enzymes;

D O I：

10.1016/j.bbrc.2005.08.121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the beginning, the microsomal HO system was presumed to be made of one isozymes, now known as HO-1, which was cytP450-dependent; and, was thought to be of physiological significance solely in the context of catalysis of hemoglobin heme to bile pigments and CO. A succession of discoveries including characterization of the system as an independent mono-oxygenase, identification of a second form, called HO-2, free radical quenching activity of bile pigments, analogous function of CO in cell signaling to NO, and characterization of the system as HSP32 cognates has led to such an impressive expansion in the number of reports dealing with the HO system that surpass anyone's expectation. This review is a compilation of certain older findings and recent events that together ensure placement of the HO system in the mainstream research for decades to come. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：568 / 577

页数：10

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