Dopamine and N-methyl-D-aspartate receptor expression in peripheral blood of patients undergoing alcohol withdrawal

被引：21

作者：

Biermann, T. ^{[1
]}

Boensch, D. ^{[1
]}

Reulbach, U. ^{[1
]}

Kornhuber, J. ^{[1
]}

Bleich, S. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, D-90154 Erlangen, Germany

来源：

JOURNAL OF NEURAL TRANSMISSION | 2007年 / 114卷 / 08期

关键词：

dopamine receptor; NMDA receptor; mRNA; alcohol withdrawal;

D O I：

10.1007/s00702-007-0661-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of the present pilot study was to explore whether a change in cerebral receptors can be demonstrated in human peripheral blood lymphocytes during alcohol withdrawal. Dopamine (D1 and D2) and NMDA (1 and 2B) receptor expressions of 14 male patients suffering from alcohol-dependency were assessed through quantitative RT-PCR. A significant difference in D1 receptor expression (T = 2.361; p = 0.035) in terms of up-regulation could be shown, though there were no significant changes concerning D2, NMDA1 or NMDA2B receptor expression.

引用

页码：1081 / 1084

页数：4

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