Hypothalamic pituitary gonadal axis dysregulation in depressed women

被引：31

作者：

Meller, WH

Grambsch, PL

Bingham, C

Tagatz, GE

机构：

[1] Fairview Univ Med Ctr, Dept Psychiat, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Biostat, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Stat, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Gynecol, Minneapolis, MN 55455 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 2001年 / 26卷 / 03期

关键词：

depression; hypothalamic-pituitary-gonadal; dysregulation; neuroendocrinology;

D O I：

10.1016/S0306-4530(00)00050-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In order to examine HPG axis regulation in women with major depression, leuteinizing hormone (LH) pulsativity was studied in 26 depressed and 24 normal women. Blood was sampled every 10 min for an 8-h period during the first week of their menstrual cycle. LH pulsatile release was analyzed using the computerized cluster analysis algorithm of Veldhuis and Johnson and spectral analysis. Compared to control women, depressed women had slower frequency dysrhythmic LH pulsatility. These results are consistent with a previously published pilot study which reported results of the first 23 subjects [Am. J. Psychiat. 154 (1997) 1454]. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：253 / 259

页数：7

共 20 条

[1]

[Anonymous], 1978, Schedule for Affective Disorders and Schizophrenia-Change version

[2]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[3] DIFFERENTIAL FERTILITY IN BIPOLAR AFFECTIVE-ILLNESS [J].