Integrative mathematical oncology

被引：297

作者：

Anderson, Alexander R. A. ^{[1
]}

Quaranta, Vito ^{[2
]}

机构：

[1] Univ Dundee, Div Math, Dundee DD1 4HN, Scotland

[2] Vanderbilt Univ, Sch Med, Dept Canc Biol, Nashville, TN 37232 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 03期

关键词：

D O I：

10.1038/nrc2329

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer research attracts broad resources and scientists from many disciplines, and has produced some impressive advances in the treatment and understanding of this disease. However, a comprehensive mechanistic view of the cancer process remains elusive. To achieve this it seems clear that one must assemble a physically integrated team of interdisciplinary scientists that includes mathematicians, to develop mathematical models of tumorigenesis as a complex process. Examining these models and validating their findings by experimental and clinical observations seems to be one way to reconcile molecular reductionist with quantitative holistic approaches and produce an integrative mathematical oncology view of cancer progression.

引用

页码：227 / 234

页数：8

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