Dynamics of human immunodeficiency virus type 1 replication in vertically infected infants

被引：67

作者：

Luzuriaga, K

Wu, HL

McManus, M

Britto, P

Borkowsky, W

Burchett, S

Smith, B

Mofenson, L

Sullivan, JL

机构：

[1] Univ Massachusetts, Sch Med, Dept Pediat, Program Mol Med, Worcester, MA 01605 USA

[2] Harvard Univ, Sch Publ Hlth, Stata & Data Anal Ctr, Boston, MA 02115 USA

[3] Boston Childrens Hosp, Boston, MA USA

[4] NYU, Dept Pediat, New York, NY USA

[5] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA

[6] NICHHD, Pediat Adolescent & Maternal AIDS Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 01期

关键词：

D O I：

10.1128/JVI.73.1.362-367.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.

引用

页码：362 / 367

页数：6

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