The lateral pressure profile in membranes: a physical mechanism of general anesthesia

被引：58

作者：

Cantor, RS ^{[1
]}

机构：

[1] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA

来源：

TOXICOLOGY LETTERS | 1998年 / 101卷

关键词：

lipid-mediated mechanism; lateral pressure; alkanol cutoff; perfluorocarbons;

D O I：

10.1016/S0378-4274(98)00220-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1. A lipid-mediated mechanism of general anesthesia is suggested and investigated using lattice statistical thermodynamics. 2. Anesthetics are predicted to shift the distribution of lateral pressure within a lipid bilayer, and thus alter the mechanical work required to open ion channel proteins, if channel opening is accompanied by a non-uniform change in cross-sectional area of the protein. 3. Calculations based on this mechanical thermodynamic hypothesis yield qualitative agreement with anesthetic potency at clinical anesthetic membrane concentrations, and predict the alkanol cutoff and anomalously low potencies of strongly hydrophobic molecules with little attraction for the aqueous interface, such as perfluorocarbons. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：451 / 458

页数：8

共 28 条

[11] WHAT IS THE MOLECULAR NATURE OF GENERAL ANESTHETIC TARGET SITES [J].