PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization

被引:83
作者
Yue, Q
Groszer, M
Gil, JS
Berk, AJ
Messing, A
Wu, H
Liu, X [1 ]
机构
[1] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[4] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53705 USA
[5] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA
[6] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
来源
DEVELOPMENT | 2005年 / 132卷 / 14期
关键词
PTEN; Bergmann glia; cerebellar development; mouse;
D O I
10.1242/dev.01891
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Development of the central nervous system is controlled by both intrinsic and extrinsic signals that guide neuronal migration to form laminae. Although defects in neuronal mobility have been well documented as a mechanism for abnormal laminar formation, the role of radial glia, which provide the environmental cues, in modulating neuronal migration is less clear. We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this crucial cell population and subsequently to extensive layering defects. Accordingly, severe granule neuron migration defects and abnormal laminar formation are observed. These results uncover an unexpected role for PTEN in regulating Bergmann glia differentiation, as well as the importance of time-dependent Bergmann glia differentiation during cerebellar development.
引用
收藏
页码:3281 / 3291
页数:11
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