The Role of Atg Proteins in Autophagosome Formation

被引：2344

作者：

Mizushima, Noboru ^{[1
]}

Yoshimori, Tamotsu ^{[2
]}

Ohsumi, Yoshinori ^{[3
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo 1138519, Japan

[2] Osaka Univ, Dept Genet, Grad Sch Med, Suita, Osaka 5650871, Japan

[3] Tokyo Inst Technol, Frontier Res Ctr, Yokohama, Kanagawa 2268503, Japan

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 | 2011年 / 27卷

关键词：

autophagy; autophagosome; Atg; preautophagosomal structure; isolation membrane; PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES; VACUOLE TARGETING PATHWAY; ENDOPLASMIC-RETICULUM; VESICLE FORMATION; KINASE COMPLEX; MAMMALIAN DEVELOPMENT; ISOLATION MEMBRANES; CONJUGATION SYSTEM; MEDIATED AUTOPHAGY; REGULATE AUTOPHAGY;

D O I：

10.1146/annurev-cellbio-092910-154005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane reorganization. Since the discovery of yeast Atg-related proteins, autophagosome formation has been dissected at the molecular level. In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.

引用

页码：107 / 132

页数：26

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