SNX3 regulates endosomal function through its PX-domain-mediated interaction with Ptdlns(3)P

被引：247

作者：

Xu, Y ^{[1
]}

Hortsman, H ^{[1
]}

Seet, L ^{[1
]}

Wong, SH ^{[1
]}

Hong, W ^{[1
]}

机构：

[1] Inst Mol & Cell Biol, Membrane Biol Lab, Singapore 117609, Singapore

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 07期

关键词：

D O I：

10.1038/35083051

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The sorting nexin (SNX) protein family is implicated in regulating membrane traffic, but the mechanism is still unknown, We show that SNX3 is associated with the early endosome through a novel motif (PX domain) capable of interaction with phosphatidylinositol-3-phosphate (Ptdlns(3)P), Overexpression of SNX3 alters endosomal morphology and delays transport to the lysosome, Transport from the early to the recycling endosome is affected upon microinjection of SNX3 antibodies, Our results highlight a novel mechanism by which SNX proteins regulate traffic and uncover a novel class of effecters for Ptdlns(3)P.

引用

页码：658 / 666

页数：9

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