The antidepressant fluoxetine restores plasticity in the adult visual cortex

被引：639

作者：

Maya-Vetencourt, Jose Fernando ^{[1
]}

Sale, Alessandro ^{[1
]}

Viegi, Alessandro ^{[1
]}

Baroncelli, Laura ^{[1
]}

De Pasquale, Roberto ^{[1
]}

O'Leary, Olivia F.

Castren, Eero ^{[3
]}

Maffei, Lamberto ^{[1
,2
]}

机构：

[1] Scuola Normale Super Pisa, I-56100 Pisa, Italy

[2] CNR, Inst Neurosci, I-56100 Pisa, Italy

[3] Univ Helsinki, Ctr Neurosci, FIN-00014 Helsinki, Finland

来源：

SCIENCE | 2008年 / 320卷 / 5874期

关键词：

D O I：

10.1126/science.1150516

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat. We found that chronic administration of fluoxetine reinstates ocular dominance plasticity in adulthood and promotes the recovery of visual functions in adult amblyopic animals, as tested electrophysiologically and behaviorally. These effects were accompanied by reduced intracortical inhibition and increased expression of brain- derived neurotrophic factor in the visual cortex. Cortical administration of diazepam prevented the effects induced by fluoxetine, indicating that the reduction of intracortical inhibition promotes visual cortical plasticity in the adult. Our results suggest a potential clinical application for fluoxetine in amblyopia as well as new mechanisms for the therapeutic effects of antidepressants and for the pathophysiology of mood disorders.

引用

页码：385 / 388

页数：4

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