Circulating endothelial progenitor cells

被引:60
作者
Garmy-Susini, B [1 ]
Varner, JA [1 ]
机构
[1] Univ Calif San Diego, John & Rebecca Moores Comprehens Canc Ctr, La Jolla, CA 92093 USA
关键词
angiogenesis; stem cell; endothelial progenitor cell; CD34(+) cell; monocyte;
D O I
10.1038/sj.bjc.6602808
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Angiogenesis research investigates the formation of new blood vessels in wound healing, tumour growth and embryonic development. Circulating, bone marrow-derived endothelial progenitor cells (EPCs) were first described 8 years ago, yet the exact nature of these endothelial precursor cells remains unclear. The contributions of circulating EPCs to angiogenesis in tumours, ischaemic injury and other diseases as well as their usefulness in the repair of wounded hearts and limbs remain under intense investigation.
引用
收藏
页码:855 / 858
页数:4
相关论文
共 39 条
[31]  
SENGER DR, 1986, CANCER RES, V46, P5629
[32]   Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: Implications for cellular surrogate marker analysis of antiangiogenesis [J].
Shaked, Y ;
Bertolini, F ;
Man, S ;
Rogers, MS ;
Cervi, D ;
Foutz, T ;
Rawn, K ;
Voskas, D ;
Dumont, DJ ;
Ben-David, Y ;
Lawler, J ;
Henkin, J ;
Huber, J ;
Hicklin, DJ ;
D'Amato, RJ ;
Kerbel, RS .
CANCER CELL, 2005, 7 (01) :101-111
[33]   The role of tumor lymphangiogenesis in metastatic spread [J].
Stacker, SA ;
Baldwin, ME ;
Achen, MG .
FASEB JOURNAL, 2002, 16 (09) :922-934
[34]   Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model [J].
Taguchi, A ;
Soma, T ;
Tanaka, H ;
Kanda, T ;
Nishimura, H ;
Yoshikawa, H ;
Tsukamoto, Y ;
Iso, H ;
Fujimori, Y ;
Stern, DM ;
Naritomi, H ;
Matsuyama, T .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (03) :330-338
[35]   A role for hematopoietic stem cells in promoting angiogenesis [J].
Takakura, N ;
Watanabe, T ;
Suenobu, S ;
Yamada, Y ;
Noda, T ;
Ito, Y ;
Satake, M ;
Suda, T .
CELL, 2000, 102 (02) :199-209
[36]   Cathepsin L is required for endothelial progenitor cell-induced neovascularization [J].
Urbich, C ;
Heeschen, C ;
Aicher, A ;
Sasaki, K ;
Bruhl, T ;
Farhadi, MR ;
Vajkoczy, P ;
Hofmann, WK ;
Peters, C ;
Pennacchio, LA ;
Abolmaali, ND ;
Chavakis, E ;
Reinheckel, T ;
Zeiher, AM ;
Dimmeler, S .
NATURE MEDICINE, 2005, 11 (02) :206-213
[37]   Multistep nature of microvascular recruitment of Ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesis [J].
Vajkoczy, P ;
Blum, S ;
Lamparter, M ;
Mailhammer, R ;
Erber, R ;
Engelhardt, B ;
Vestweber, D ;
Hatzopoulos, AK .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (12) :1755-1765
[38]   Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties [J].
Wang, LS ;
Li, L ;
Shojaei, F ;
Levac, K ;
Cerdan, C ;
Menendez, P ;
Martin, T ;
Rouleau, A ;
Bhatia, M .
IMMUNITY, 2004, 21 (01) :31-41
[39]   Expansion of myeloid immune suppressor Gr+CD11b+cells in tumor-bearing host directly promotes tumor angiogenesis [J].
Yang, L ;
DeBusk, LM ;
Fukuda, K ;
Fingleton, B ;
Green-Jarvis, B ;
Shyr, Y ;
Matrisian, LM ;
Carbone, DP ;
Lin, PC .
CANCER CELL, 2004, 6 (04) :409-421