The allergen bronchoprovocation model: an important tool for the investigation of new asthma anti-inflammatory therapies

被引:58
作者
Boulet, L.-P.
Gauvreau, G.
Boulay, M.-E.
O'Byrne, P.
Cockcroft, D. W.
机构
[1] Hop Laval, Unite Tech Pneumol, Inst Cardiiol & Pneumol, Quebec City, PQ G1V 4G5, Canada
[2] McMaster Univ, Med Ctr, Dept Med, Hamilton, ON, Canada
[3] Univ Saskatchewan, Royal Univ Hosp, Div Resp & Crit Care, Dept Med, Saskatoon, SK, Canada
关键词
airway inflammation; allergen bronchoprovocations; allergen challenges; asthma; asthma treatment;
D O I
10.1111/j.1398-9995.2007.01499.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Allergen bronchoprovocation tests have been used for more than two decades in the investigation of respiratory allergic diseases such as asthma and rhinitis. These bronchial challenges are now well standardized and can offer key information on the therapeutic potential of new agents and on their anti-inflammatory effects on the airways. Both standard and low-dose allergen provocations are safe when performed by experienced investigators and do not lead to persistent worsening of asthma or change in airway function. The evaluation of new therapeutic agents by these methods can also provide important information on the mechanisms of development and persistence of airway diseases.
引用
收藏
页码:1101 / 1110
页数:10
相关论文
共 119 条
[1]  
ADACHI M, 1984, PHARMATHERAPEUTICA, V4, P36
[2]  
ALTOUNYAN R. E. C., 1964, THORAX, V19, P406, DOI 10.1136/thx.19.5.406
[3]  
[Anonymous], 1987, AM REV RESPIR DIS, V136, P225
[4]   New therapies for asthma [J].
Barnes, Peter J. .
TRENDS IN MOLECULAR MEDICINE, 2006, 12 (11) :515-520
[5]   Structural changes in airway diseases - Characteristics, mechanisms, consequences, and pharmacologic modulation [J].
Bergeron, C ;
Boulet, LP .
CHEST, 2006, 129 (04) :1068-1087
[6]  
Blackley C, 1873, EXPT RESEARCHES CAUS
[7]   Allergy and asthma [J].
Bochner, BS ;
Busse, WW .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 115 (05) :953-959
[8]  
BOOIJ-NOORD H, 1972, Clinical Allergy, V2, P43, DOI 10.1111/j.1365-2222.1972.tb01267.x
[9]   IMMEDIATE AND LATE BRONCHIAL OBSTRUCTIVE REACTIONS TO INHALATION OF HOUSE DUST AND PROTECTIVE EFFECTS OF DISODIUM CROMOGLYCATE AND PREDNISOLONE [J].
BOOIJNOORD, H ;
ORIE, NGM ;
DEVRIES, K .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1971, 48 (06) :344-+
[10]   The relationships between atopy, rhinitis and asthma: pathophysiological considerations [J].
Boulay, Marie-Eve ;
Boulet, Louis-Philippe .
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 3 (01) :51-55