The human thymus during aging

被引：103

作者：

Haynes, BF

Sempowski, GD

Wells, AF

Hale, LP

机构：

[1] Duke Univ, Arthrit Ctr, Dept Med, Durham, NC USA

[2] Duke Univ, Arthrit Ctr, Dept Pathol, Durham, NC USA

[3] Duke Univ, Arthrit Ctr, Dept Immunol, Durham, NC USA

[4] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC USA

来源：

IMMUNOLOGIC RESEARCH | 2000年 / 22卷 / 2-3期

关键词：

thymus; immune reconstitution; T cells;

D O I：

10.1385/IR:22:2-3:253

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adult thymus can produce significant numbers of new T cells. Until recently, no assays were available to directly evaluate postnatal thymic function. This paper reviews work on human thymic aging at Duke University School of Medicine and discusses the relevance of this work to devising new strategies for T cell immune reconstitution in man.

引用

页码：253 / 261

页数：9

共 41 条

[31] Defective IL7R expression in T-B+NK+ severe combined immunodeficiency [J].