Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease

被引：125

作者：

D'Arena, Giovanni ^{[1
]}

Laurenti, Luca ^{[2
]}

Minervini, Maria Marta ^{[1
]}

Deaglio, Silvia ^{[3
]}

Bonello, Lisa ^{[4
]}

De Martino, Laura ^{[5
]}

De Padua, Laura ^{[2
]}

Savino, Lucia ^{[1
]}

Tarnani, Michela ^{[2
]}

De Feo, Vincenzo ^{[5
]}

Cascavilla, Nicola ^{[1
]}

机构：

[1] IRCCS Casa Sollievo Sofferenza, Hematol & Stem Cell Transplantat Unit, I-71013 San Giovanni Rotondo, Italy

[2] Univ Cattolica Sacro Cuore, Hematol Chair, I-00168 Rome, Italy

[3] Univ Turin, Immunogenet Lab, Turin, Italy

[4] Univ Turin, CeRMS, Turin, Italy

[5] Univ Salerno, Dept Pharmaceut Sci, I-84100 Salerno, Italy

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 03期

关键词：

Regulatory T-cells; Chronic lymphocytic leukemia; Immune system; Disregulation; Autoimmunity; Flow cytometry; CD127; SUPPRESSIVE FUNCTION; IMMUNE-RESPONSES; EXPRESSION; CANCER; FLUDARABINE; RITUXIMAB; THERAPY; CD38;

D O I：

10.1016/j.leukres.2010.08.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：363 / 368

页数：6

共 27 条

[1] CD4+CD25high regulatory cells in human peripheral blood [J].

Baecher-Allan, C ;

Brown, JA ;

Freeman, GJ ;

Hafler, DA .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1245-1253

[2] Human regulatory T cells and their role in autoimmune disease [J].

Baecher-Allan, Clare ;

Hafler, David A. .

IMMUNOLOGICAL REVIEWS, 2006, 212 :203-216

[3] The Fate of Human Treg Cells [J].

Battaglia, Manuela ;

Roncarolo, Maria Grazia .

IMMUNITY, 2009, 30 (06) :763-765

[4] Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine [J].

Beyer, M ;

Kochanek, M ;

Darabi, K ;

Popov, A ;

Jensen, M ;

Endl, E ;

Knolle, PA ;

Thomas, RK ;

von Bergwelt-Baildon, M ;

Bebey, S ;

Hallek, M ;

Schultze, JL .

BLOOD, 2005, 106 (06) :2018-2025

[5] Regulatory T cells in cancer [J].

Beyer, Marc ;

Schultze, Joachim L. .

BLOOD, 2006, 108 (03) :804-811

[6] Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia [J].

Byrd, John C. ;

Kipps, Thomas J. ;

Flinn, Ian W. ;

Castro, Januaro ;

Lin, Thomas S. ;

Wierda, William ;

Heerema, Nyla ;

Woodworth, James ;

Hughes, Steve ;

Tangri, Shabnam ;

Harris, Sarah ;

Wynne, Dee ;

Molina, Arturo ;

Leigh, Bryan ;

O'Brien, Susan .

BLOOD, 2010, 115 (03) :489-495

[7] In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia [J].

Calissano, Carlo ;

Damle, Rajendra N. ;

Hayes, Gregory ;

Murphy, Elizabeth J. ;

Hellerstein, Marc K. ;

Moreno, Carol ;

Sison, Cristina ;

Kaufman, Matthew S. ;

Kolitz, Jonathan E. ;

Allen, Steven L. ;

Rai, Kanti R. ;

Chiorazzi, Nicholas .

BLOOD, 2009, 114 (23) :4832-4842

[8] Role of regulatory T cells in human diseases [J].

Chatila, TA .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (05) :949-959

[9] Mechanisms of disease: Chronic lymphocytic leukemia [J].

Chiorazzi, N ;

Rai, KR ;

Ferrarini, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) :804-815

[10] Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy [J].

Colombo, Mario P. ;

Piconese, Silvia .

NATURE REVIEWS CANCER, 2007, 7 (11) :880-887

← 1 2 3 →