The emerging role of adipokines in osteoarthritis: a narrative review

被引：74

作者：

Hu, Peng-fei ^{[1
,2
]}

Bao, Jia-peng ^{[1
,2
]}

Wu, Li-dong ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Coll Med, Hosp 2, Dept Orthoped Surg, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Coll Med, Hangzhou 310009, Zhejiang, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2011年 / 38卷 / 02期

关键词：

Adipokines; Osteoarthritis; Leptin; Adiponectin; Resistin; Visfatin; COLONY-ENHANCING FACTOR; NF-KAPPA-B; REGULATES INSULIN-SECRETION; PRO-INFLAMMATORY CYTOKINES; MESSENGER-RNA EXPRESSION; SYNTHASE TYPE-II; LEPTIN RECEPTOR; RHEUMATOID-ARTHRITIS; KNEE OSTEOARTHRITIS; MATRIX DEGRADATION;

D O I：

10.1007/s11033-010-0179-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly individuals. OA is affecting severely the quality of life of patients, while the causes of OA are not completely understood. Age, obesity, the female sex, and previous injury are considered as significant risk factors. Recently, increased levels of adipokines which are mainly produced by adipocytes have been detected in patients with osteoarthritis. Moreover, studies on different adipokines all reveal that they have played proinflammatory and catabolic/anabolic roles during the pathophysiology of OA. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones leptin, adiponectin, resistin and visfatin on initiation and progression of OA.

引用

页码：873 / 878

页数：6

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